The patient: A 20-year-old woman in the United Kingdom
The symptoms: The patient had unprotected vaginal sex with her habitual male partner, and shortly afterward, her vulva and vagina began itching and swelling. She developed angioedema — swelling of the tissues below the surface of the skin — and hives appeared across her body. She also felt faint and short of breath.
What happened next: The woman visited a hospital and was given 10 milligrams of cetirizine, an oral antihistamine that’s typically used to treat hives and allergies. She was already aware that she was severely allergic to Brazil nuts, a type of tree nut, but it was unclear what triggered her allergic reaction in this instance.
She noted that her partner had eaten Brazil nuts about two to three hours before they had sex, but he had taken a bath and thoroughly cleaned his teeth and fingernails prior to intercourse.
The diagnosis: Due to the patient’s medical history, doctors at the hospital suspected that vaginal sex introduced allergy-triggering proteins from Brazil nuts into the woman’s body by way of her partner’s semen.
They conducted skin prick tests on the patient using different semen samples from her partner; this involved exposing small regions of skin to each sample. For one test, the doctors used a sample taken when the man had not recently eaten nuts. The other test used a sample collected about 2.5 hours after he ate Brazil nuts. In the latter test, a 0.28-inch-long (7 millimeters) welt appeared on the woman’s skin. That suggested that Brazil nut allergens were behind her severe postcoital allergic reaction.
The treatment: Within 45 minutes after she took the cetirizine, the woman’s symptoms began to improve. She felt tired the next day but did not have any hives or feel dizzy, nor did she have trouble breathing. The doctors instructed her to keep antihistamines and an adrenaline pen (otherwise known as an EpiPen) close by and suggested that, in the future, she should abstain from sexual intimacy with her partner if he had recently eaten Brazil nuts.
What makes the case unique: There are other documented cases of individuals with severe allergies developing local allergic reactions after intimate contact. However, the culprit is usually the direct transfer of allergens through touch or kissing. In other words, the allergen is present on a person’s hands or mouth and then gets passed over.
“To our knowledge this is the first case of a severe food allergic reaction transferred by normal vaginal intercourse,” doctors at the hospital wrote in a report.
This article is for informational purposes only and is not meant to offer medical advice.
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